Rectal administration of feprazone in healthy volunteers [letter].
نویسندگان
چکیده
منابع مشابه
Oral versus rectal ibuprofen in healthy volunteers.
OBJECTIVE Ibuprofen is a safe and effective non steroidal anti-inflammatory drug (NSAID). Ibuprofen suppositories are marketed in Europe; but data regarding pharmacokinetics of rectal vs. oral ibuprofen in humans is scarce. The objective of this study is to compare the pharmacokinetics of single-dose rectal vs. oral ibuprofen in healthy adult volunteers. METHODS Ten healthy adult male volunte...
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BACKGROUND We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers. METHODS Mianserin suppositories were prepared by a melting technique using Tetramide® tablets and Witepsol H-15 as the suppository base. Pharmacokinetics of this 30-mg mianserin preparation were evalua...
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Paracetamol is usually given in adults at a dose of 10-20 mg kg(-1) orally or rectally. Work in children suggests that doses of 40 mg kg(-1) are needed to provide therapeutic concentrations when this drug is used by the rectal route. We have investigated the dose of rectal paracetamol needed to achieve serum concentrations within the accepted therapeutic range of 10-20 microg ml(-1) in adults. ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1976
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1976.tb00616.x